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The transfusion of blood components may trigger an allergic reaction ranging from complaints of hives and itching to wheezing, fever or even anaphylaxis and anaphylactic shock, which can be fatal if not immediately treated. Allergic reactions occur when the transfusion recipient has antibodies that react with an allergen in the donor blood, usually a plasma protein (such as IgG, albumin, haptoglobin, transferrin, C3, C4 or cytokines) in the transfused blood component. Such reactions may occur in up to 1 in 200 transfusions of red blood cells and in up to 1 in 30 transfusions of platelets.