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While current screening tests have reduced the risks of transfusion-transmitted infections (TTI), a window period still exists for known pathogens such as HIV, HBV and HCV. Hence there is still a potential risk that a patient may be infected if the donor has donated in the early stage of infection.

However, when platelet concentrates from donors in the early stage of infection are treated with the INTERCEPT™ Blood System, the replication of DNA and RNA will be blocked, preventing the proliferation of the pathogen and the subsequent infection of the patient.

In addition, screening panels may differ by country, as the prevalence of a pathogen may differ by geography. This means that a patient may be infected with a known pathogen which is not part of a country’s standard screening panel. The INTERCEPT Blood System prevents transmission as described above, by blocking the replication of DNA and RNA, preventing the proliferation of the pathogen and any infection of the patient.