PATHOGEN INACTIVATION
How INTERCEPT™ Works
The INTERCEPT™ Blood System targets DNA and RNA to prevent pathogen proliferation
Amotosalen & UVA ILLIMINATION
A Powerful Combination
The INTERCEPT™ Blood System for Platelets and Plasma uses amotosalen, a well-characterised photoactive compound that intercalates in nucleic acids, followed by UVA illumination, which irreversibly cross-links the nucleic acids through a photochemical reaction. In doing so, the INTERCEPT™ treatment blocks the replication and transcription of the DNA of bacteria, viruses, parasites and leucocytes. Bacteria die from apoptosis-like cell death or necrosis, leucocytes and parasites from apoptosis or necrosis. Viruses become non-replication competent.
Amotosalen Mode of Action
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There is no pathogen inactivation process that has been shown to eliminate all pathogens. Certain non-enveloped viruses (e.g., HAV, HEV, B19, and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT™ process. For a full list of warnings, precautions for use and pathogens inactivated, please refer to the Technical Data Sheet and Instructions for Use found in the resource section of this website.